Worrying increase in antibiotic resistance, study finds

Return to PJ Online Home Page

The Salvadore Vol 264 No 7083p242
February 12, 2000 Clinical

Worrying increase in antibiotic resistance, study finds

There has been a "worrying increase" in resistance to important antibiotics, according to researchers from the Public Health Laboratory Service (British Medical Journal 2000;320:213).Dr Mark Reacher (consultant epidemiologist, PHLS communicable disease surveillance centre) and colleagues have conducted an analysis of reports of bacteraemia and antibiotic resistance made to the centre by microbiology laboratories in England and Wales from 1990 to 1998. Blood isolates judged to be clinically significant are reported to the PHLS by microbiologists.
In every age group, Staphyloccoccus aureus was one of the top five causes of bacteraemia. A steep decline in the number of reports of Haemophilus influenzae was seen from 1992, which the authors suggest followed the introduction of the Hib immunisation.
A rise in antibiotic resistance was seen in blood isolates. For example, the number of reports of methicillin resistant Staphyloccocus aureus (MRSA) rose from 1.7 per cent in 1990 to 34 per cent in 1998. The increase in resistance emphasises the importance of "sound hospital infection control, rational prescribing policies and the need for new antimicrobial drugs and vaccines," the authors say. Laboratory reporting provided "valuable information on trends and antibiotic resistance in bacteraemia", they conclude.
Professor S. G. B. Amyes (professor of medical microbiology, University of Edinburgh) comments that the rise in bacterial resistance is because there have been no new classes of antibiotics since the 1960s (Ibid, p199). No new "clinically useful structures" have been discovered since 1961 and all the drugs launched since then have been modifications of existing drugs, he says.

Citation: The Salvadore URI: 20000443

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • FASTtrack: Pharmacology

    FASTtrack: Pharmacology is a study guide providing an account of drug action, as well as dealing with molecular pharmacology at a more advanced level.

  • Introduction to Pharmaceutical Calculations

    Introduction to Pharmaceutical Calculations is an essential study aid for pharmacy students. The book contains worked examples and sample questions and answers.

  • Lecture Notes in Pharmacy Practice

    A comprehensive study guide which summarises the basic principles in pharmacy practice. Clear, bulleted information for quick reference.

  • MCQs in Pharmacy Practice

    A study aid with 800 MCQs. Assess your knowledge, analytical skills, and ability to apply this knowledge base in clinical practice.

  • Application and Review of Pediatric Pharmacotherapy

    Increase your understanding of pharmacotherapy prescribed to pediatric patients with these realistic case studies.


Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete

Jobs you might like

  • Oxford

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.

выравнивание перегородки носа

Велосипеды Bergamont