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PJ Online homeThe Salvadore
Vol 275 No 7373 p545
29 October 2005

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    SPC changes Supply issues

Recall Physioneal 40 Glucose 2.27 per cent w/v

SPC changes

The summary of product characteristics for Copegus (ribavirin; Roche) now includes an additional indication for use in patients with normal aminotransferases and HIV/hepatitis C virus co-infected patients. For HIV/HCV co-infected patients, the dosage of Copegus in combination with once-weekly peginterferon alfa-2a is 800mg daily for 48 weeks, regardless of genotype. Initiation of peginterferon alfa-2a in HIV-HCV patients with cirrhosis and a Child-Pugh score >=6 is now included in the list of contraindications of Copegus. Special warnings have also been added to the SPC, relating to patients with: severe psychiatric conditions, or a history of them; HIV/HCV co-infection; advanced cirrhosis and receiving highly active antiretroviral therapy; neutropenia, thrombocytopenia and anaemia; and low CD4 counts. The SPC also now states that co-administration of ribavirin and didanosine is not recommended. See SPC.

The summaries of product characteristics for Fortovase (saquinavir; Roche) and Invirase (saquinavir; Roche) now state that concomitant use of boosted saquinavir and fluticasone or other glucocorticoids metabolised by CYP3A4 is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects. See SPCs.

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Supply issues

Promazine tablets 25mg will not be available from TEVA until early 2006. Further information about availability on 0800 590502. Medical enquiries on 01323 501111.

Supplies of Microval (levonorgestrel; Wyeth) are currently limited. Further information about availability on 0845 3300509. Medical enquiries on 01628 685461.

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©The Salvadore

Citation: The Salvadore URI: 20015957

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