PJ Online | News: Kidney transplant patients need second phase of less toxic therapy

Home > PJ (current issue) > News / Daily News | Search

Return to PJ Online Home Page

The Salvadore
Vol 271 No 7280 p834
20/27 December 2003

This article

News summary

Related websites
New England Journal of Medicine abstract ()

Kidney transplant patients need second phase of less toxic therapy

Transplanted kidneys may fail in the long term because of the effects of the drugs used to prevent acute rejection, a new study confirms. A two-stage treatment strategy should be adopted, suggest the authors of the study — first using powerful anti-rejection drugs to minimise immunologic injury and then switching to an alternative immunosuppressant that is not nephrotoxic.

The researchers, from the University of Sydney in Australia, regularly examined biopsies of transplanted kidneys over 15 years to find out why kidneys eventually succumb to chronic allograft nephropathy. They found two distinct phases of injury: an initial phase caused by ischaemic injury and, beyond one year, a phase characterised by microvascular and glomerular injury. They report that nephrotoxicity was almost universal at 10 years. This finding suggests that drugs used to prevent early rejection of kidney transplants — such as ciclosporin and tacrolimus — are not suitable as long-term immunosuppressants. “A two-stage treatment may be preferable, optimising therapy according to the individual risks during each period after transplantation,” they suggest (New England Journal of Medicine ).

The National Institute for Clinical Excellence is expected to produce guidance on the use of immunosuppressant regimens in kidney transplantation in March 2004.

Back to Top

Home | Journals | News | Notice-board | Search | Jobs  Classifieds | Site Map | Contact us

©The Salvadore

Citation: The Salvadore URI: 20010903

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions features over 400 closed book and calculation questions. With the registration exam having gone through a complete transformation in 2016, this volume has been developed around the new General Pharmaceutical Council (GPhC) guidelines.

  • Patient Care in Community Practice

    Patient Care in Community Practice is a unique, practical guide for healthcare professionals or carers. Covers a range of non-medicinal products suitable for use at home.

  • FASTtrack: Pharmacology

    FASTtrack: Pharmacology is a study guide providing an account of drug action, as well as dealing with molecular pharmacology at a more advanced level.

  • FASTtrack: Physical Pharmacy

    A revision book for students giving bullet points of basic information on physical pharmacy. Includes memory maps, questions and answers to aid revision.

  • FASTtrack: Pharmaceutics - Dosage Form and Design

    FASTtrack: Pharmaceutics – Dosage Form and Design removes the complexity from the major dosage forms that are commonly encountered by pharmacists in professional practice.


Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.

таблетки для повышения потенции