Preconception blood pressure linked to pregnancy loss risk

Research has shown that high blood pressure before conception is linked to a higher risk of pregnancy loss, independent of known risk factors.

Interventions to reduce blood pressure may help to improve reproductive outcomes in healthy young women, research has found[1].

In a paper published in Hypertension (2 April 2018), researchers used data from a trial of aspirin on reproductive outcomes to study preconception blood pressure in 1,228 women with a history of pregnancy loss who were trying to get pregnant.

The researchers found no clear link between blood pressure and time to pregnancy or live birth rate. However, each 10mmHg increase in preconception diastolic blood pressure was associated with an 18% increase in the risk of pregnancy loss and each 10mmHg increase in preconception mean arterial pressure was associated with a 17% increase.

“Our findings do suggest that preconception blood pressure is a marker of increased risk of pregnancy loss, independent of age, [body mass index], and other risk factors, and add to the evidence base suggesting that early markers of cardiometabolic risk may be associated with adverse reproductive events,” said the researchers.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2018.20204909

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Rules and Guidance for Pharmaceutical Manufacturers and Distributors 2017 (The Orange Guide)

    Commonly known as the Orange Guide, this book is an essential reference for all involved in the manufacture or distribution of medicines in Europe.

  • Palliative Care Formulary (PCF6)

    Palliative Care Formulary is a comprehensive combination of independent information about drugs used in palliative care.

  • International Research in Healthcare

    Guidance for students or researchers undertaking a multi-centre research project in health services, medicines use and professional practice.

  • Conducting Your Pharmacy Practice Research Project

    A systematic guide to the stages of the research process, from planning of the project through to dissemination of the findings.

  • Research Methods for Pharmaceutical Practice and Policy

    Provides a practical framework for conducting pharmaceutical practice and policy research. Includes examples and applications.


Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete

Supplementary images

  • Woman taking blood pressure with doctor

Jobs you might like

  • Newton Aycliffe, Durham

  • Carmarthen, Carmarthenshire (Sir Gaerfyrddin)

  • Chester, Cheshire

  • Camberley Drive in Liverpool L25 9PU and Mosley Street in Blackburn BB2 3RX

  • Belfast (City/Town)

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.