Parkinson’s disease

Laxatives may slow worsening rigidity in Parkinson's disease

Researchers found flexor muscle stiffness plateaued in Parkinson’s patients taking all types of laxatives.

Three members of the research team. From left to right: Ms Aisha Augustin BSc, Dr R John Dobbs DCH MD FRCP FBPhS and Dr Sylvia Dobbs MSc MD FRCP FBPhS

Courtesy of Sylvia Dobbs

Three members of the research team. From left to right: Aisha Augustin, John Dobbs and Sylvia Dobbs

Constipation is common among patients with Parkinson’s disease (PD) and often predates the diagnosis by decades. Previous work by researchers at King’s College in London led them to hypothesise that laxatives might ease muscle stiffness (rigidity) in PD. 

The team retrospectively studied 79 PD patients attending a gut-brain axis clinic over 374 person-years. Flexor rigidity increased by 5.5% each year but plateaued in patients who began taking laxatives, even if they weren’t receiving anti-PD medication. A similar pattern was seen with bulk, osmotic and enterokinetic laxative classes, pointing to a common mechanism. 

Reporting in the British Journal of Clinical Pharmacology (online, 21 May 2016)[1], the researchers say the results support the idea that an imbalance in gut bacteria plays a role in the pathogenesis of PD and could point to a new approach to managing rigidity using existing medicines.


Citation: Clinical Pharmacist DOI: 10.1211/CP.2016.20201206

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Pharmacy Registration Assessment Questions 2

    Pharmacy Registration Assessment Questions 2 features more than 400 entirely new, closed book and calculation questions. It can be used in conjunction with the previous volume or on its own. All questions are in line with current GPhC guidance, enabling you to prepare for the pharmaceutical pre-registration exam with confidence.

  • Handbook of Drug Administration via Enteral Feeding Tubes

    All you need to know about prescribing or administering drugs via enteral feeding tubes. Over 400 drug monographs as well as facts to inform clinical decision making.

  • Rules and Guidance for Pharmaceutical Manufacturers and Distributors 2017 (The Orange Guide)

    Commonly known as the Orange Guide, this book is an essential reference for all involved in the manufacture or distribution of medicines in Europe.

  • Physicochemical Principles of Pharmacy

    This established textbook covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body.

  • Prescribing Medicines for Children

    Prescribing Medicines for Children is designed to improve understanding on all aspects of paediatric prescribing, from the development of suitable drugs through to their practical administration.


Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete

Supplementary images

  • Close up of an elderly person's hands
  • Three members of the research team. From left to right: Aisha Augustin, John Dobbs and Sylvia Dobbs

Jobs you might like

  • London Bridge/Work from Home

  • Runcorn, Cheshire

  • Warrington, Cheshire

  • Liverpool, Merseyside

  • Ellesmere Port, Cheshire

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.

сиалис купить одесса

увеличение губ гиалуроновой кислотой киев

viagra 100