Ketamine provides short term relief from chronic migraine
A retrospective study showed that ketamine infusions improved short-term analgesia for refractory headaches
Source: Science Photo Library
Ketamine has shown promise in patients with chronic migraine and other intractable headaches, but requires further investigation.
Researchers carried out a retrospective study to evaluate the analgesic effects of ketamine infusions on 61 patients with refractory headaches who had been admitted to hospital for aggressive intravenous therapy.
The mean headache pain rating at admission was 7.5 ± 0.2 compared to 3.4 ± 0.3 on discharge. There was a statistically significant difference between the initial, lowest and end pain ratings.
The mean length of infusion was 5.1 days and the day of lowest pain rating was day 4. Patients achieved their lowest pain rating at mean ketamine rates of 30.8 ± 3.6mg/hour less than their pre-determined maximum dose of 1mg/kg/hour. Adverse effects were mild although one patient requested discontinuation.
Sub-anaesthetic ketamine infusions improved short-term analgesia for refractory headaches but research is needed to determine long-term outcomes, the researchers concluded at the Anesthesiology 2017 annual meeting (21 October 2017).
Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20204045
Recommended from Pharmaceutical Press
Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.£33.00
Essentials of Pharmacy Management is an accessible introduction to management. It provides a jump-start to leadership roles and career advancement.£43.00
Martindale: The Complete Drug Reference provides reliable, unbiased and evaluated information on drugs and medicines used throughout the world.£570.00
Addressing all common ailments, this book provides all the essential information needed for managing symptoms presented in the pharmacy.£25.00
Remington Education: Physical Pharmacy provides a simple, concise view of the concepts and applications of physical pharmacy.£38.00