Impulse-control disorders common in Parkinson’s patients taking dopamine agonists
Researchers find that after five years of follow-up, more than half of people taking dopamine agonists for management of Parkinson’s disease developed impulse-control disorders.
Use of dopamine agonists (DAs) in people with Parkinson’s disease is strongly associated with the development of impulse-control disorders (ICDs), according to the results of a study published in Neurology (20 June 2018).
The research included 411 patients who had the disease for less than five years, 86.6% of whom had taken at least one DA since disease onset.
At five years’ follow-up, 51.5% of those exposed to DAs had experienced an ICD, such as pathological gambling or compulsive shopping, eating or sexual behaviours, compared with a rate of 12.4% in those never exposed to DAs. The researchers also found a significant dose–response relationship between DA use and ICDs, and that ICDs resolved after DA discontinuation. In contrast, there was no relationship between other drugs for Parkinson’s disease and ICDs.
“Given the high cumulative incidence of ICDs in patients with PD, these adverse effects should be carefully monitored in patients ever treated with DAs,” the researchers concluded. Tools to screen patients at high risk of developing ICDs would be beneficial, they added.
Citation: Clinical Pharmacist DOI: 10.1211/CP.2018.20205298
Recommended from Pharmaceutical Press
Now in its eleventh edition, Stockley’s Drug Interactions is still the most comprehensive and authoritative international source of drug interaction information.£212.00
An introduction to the basics of accounting and financial management. Applies these principles to pharmacy practice.£38.00
The 2016 pocket guide to drug interactions and their management, for the busy healthcare professional.£31.00
Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.£38.00
This established textbook helps you differentiate between minor illnesses which can be safely managed in the pharmacy, and major diseases.£43.00