Apixaban molecular structure

Direct oral anticoagulants carry lower risk of major bleeding versus warfarin, data showSubscription

Research from primary care suggests apixaban may be the safest of the direct oral anticoagulants overall.

Woman sitting, lower back pain

Gabapentinoids ineffective for lower back pain, review findsSubscription

A review published in the Canadian Medical Association Journal has backed up guidance stating that anticonvulsants are ineffective for treating lower back pain.

Old man walking with cane

Impulse-control disorders common in Parkinson’s patients taking dopamine agonistsSubscription

Researchers find that after five years of follow-up, more than half of people taking dopamine agonists for management of Parkinson’s disease developed impulse-control disorders.

DNA

Access to personalised cardiovascular risk information boosts lifestyle changeSubscription

Research has shown that giving patients personalised information about their disease risk can motivate them to make lifestyle changes.

Scanning electron micrograph of a prostate cancer cell

Pembrolizumab effective in some men with advanced prostate cancerSubscription

A study of 258 men with otherwise untreatable prostate cancer shows that the rate of disease control or response lasting six months or more was 11%, with two patients showing complete response.

Atrial fibrillation monitor

Sleep disruption linked to atrial fibrillation riskSubscription

Sleep disruption is an important risk factor for developing atrial fibrillation, study results show.

Deaf child using hearing aid

Sodium thiosulfate lowers hearing loss risk in cisplatin-treated childrenSubscription

Sodium thiosulfate reduces the risk of hearing loss owing to cisplatin-based chemotherapy in children with hepatoblastoma, a study published in the New England Journal of Medicine (21 June 2018) has shown.

Micrograph of the jejunum affected by coeliac disease

New drug could reduce symptoms of gluten exposure in people with coeliac diseaseSubscription

A monoclonal antibody could help reduce symptoms of coeliac disease in people with the condition who are accidentally exposed to gluten, show study findings presented at Digestive Disease Week.

Middle aged person checking blood pressure

Raised blood pressure in middle age increases risk of dementiaSubscription

Researchers have found that a systolic blood pressure of 130mmHg or above at age 50 years is associated with an increased risk of dementia.

PET scan, alzheimers disease brain scan

Risk of dementia linked to level of wealth, study findsSubscription

Level of wealth in later life is associated with risk of dementia, with those with fewer financial resources at a higher risk, a new study has found.

Depression

Depression as a side effect of certain drugs needs attention, say researchersSubscription

Researchers from the United States have noted the large proportion of medicines with depression listed as a potential side effect.

Acne, close up woman's face

Spironolactone may be effective alternative to antibiotics for adult acne in womenSubscription

Researchers investigating treatment failure rates between spironolactone and oral tetracyclines have found no a significant difference, suggesting they may be equally effective.

Asthma inhaler

Dupilumab helps severe asthma patients cut glucocorticoid useSubscription

Research has shown dupilumab reduces glucocorticoid use by more than 70% and the number of severe asthma exacerbations by almost 60%.

Vitamin supplements in store

Popular vitamin supplements do not benefit cardiovascular health, review concludesSubscription

A review into the cardioprotective effect of vitamin supplementation has shown no benefit for the most common supplements

Preterm baby in incubator

Most preterm neonates receive antibiotics despite concerns over risk and benefitsSubscription

Most preterm neonates receive early antibiotic therapy despite evidence that this can be unnecessary and sometimes harmful, the results of a US study show.

X-ray of hip fracture

Alendronate may lower cardiovascular risk in hip fracture patientsSubscription

Study finds a treatment for osteoporosis may reduce the risk of cardiovascular events in people with hip fractures.

MRI scan of brain suffering from ischaemic stroke

Clopidogrel aspirin reduces stroke risk in patients with ischaemic eventsSubscription

The incidence of major ischaemic events is reduced in at-risk patients if clopidogrel is given alongside aspirin, study finds.

Human placenta

Valproate triggers changes in placenta, researchers find Subscription

In a study looking at placentas from caesarean deliveries, valproic acid had a significant impact on mRNA levels of major carriers for essential compounds such as folic acid, glucose, choline, thyroid hormones and serotonin.

EEG examination of patient with epilepsy

Antiepileptic drugs linked with increased risk of dementia, study concludesSubscription

Use of antiepileptic drugs is associated with an increased incidence of dementia in older adults, but it is unclear if this association is causal, say researchers.

Cannabidiol, bottled

Cannabidiol reduces seizure rate in rare form of epilepsySubscription

Cannabidiol reduces the risk of drop seizures in people with Lennox-Gastaut syndrome, a rare, severe form of epilepsy, according to the results of a recent study

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