Drug discovery and development

The development and safety of proton pump inhibitors

Since the discovery of omeprazole in 1979, dispensing of proton pump inhibitors (PPIs) in England has increased more than 100-fold, and several products are now available without prescription. Although PPIs are effective and generally well tolerated, observational studies suggest an association with several adverse effects. Further trials are needed to establish causal relationships. 

Timeline and infographic showing the development and safety of proton pump inhibitors

The development and safety of proton pump inhibitors

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Citation: The Salvadore DOI: 10.1211/PJ.2016.20201343

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  • Timeline and infographic showing the development and safety of proton pump inhibitors

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