Charting obesity

In the UK, the prevalence of obesity is continuing to grow, bringing with it a whole host of hidden diseases affecting a number of body systems — from cardiovascular to skeletal.   

How obesity affects the different body systems

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Obesity in the UK and OECD nations

Obesity in the UK and OECD nations

Source: Organisation for Economic Co-operation and Development (OECD)

* The Organisation for Economic Co-operation and Development (OECD) includes 35 member countries from North and South America to Europe and Asia-Pacific
** Self-reported

Obesity and the cardiovascular system

Cardiovascular system

Source: Obesity Action, NHS Digital

Obese individuals have more fatty tissue, which increases their vascular resistance and in turn increases the work the heart has to do. They are at greater risk of hypertension and heart disease.

Obesity and the digestive and skeletal systems

Digestive and skeletal systems

Source: Digestive system: Obesity Action, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute; Skeletal system: Johns Hopkins Arthritis Center

Obesity increases the risk of gastro-oesophageal reflux disease (GORD) because fat exerts pressure on the stomach. It also increases the risk of gallstones because of increased cholesterol in bile, and of non-alcoholic fatty liver disease.

Excessive loading of weight-bearing joints, such as the knees and hips, along with poor posture means that obese individuals are at an increased risk of developing osteoarthritis (OA).

Obesity and the central nervous system

Central nervous system

Source: Science Daily, Arch Gen Psychiatry 2010;67:227, Stroke 2010;41:e421

Obese people are more likely to become depressed because of poor health or being unhappy with their appearance. In addition, people who are depressed are more likely to become obese because of physiological changes in the hormone and immune systems.

Obesity and the respiratory system

Respiratory system

Source: NHS Choices, Thorax 2008;63:651

Excess body fat around the neck and stomach can lead to breathing difficulties causing sleep apnoea. It is also thought that there is a link between obesity and asthma but the mechanisms are not fully understood.

Obesity and the endocrine system

Endocrine system

Source:, NHS Digital (2017), BMC Public Health 2009;9:16

Obese people have enlarged fat cells that contain more fat. This is associated with increased inflammation and impaired metabolic function, and can lead to insulin resistance, the hallmark of type 2 diabetes.

Obesity and additional risks for women 17

Additional risks for women

Source: National Cancer Institute, NHS Choices

Being overweight increases the risk of complications for pregnant women and their babies as well as making it more difficult to conceive.

*Body mass index (BMI) is a surrogate marker of body fat which does not take account of factors such as age, sex, ethnicity, and muscle mass.

BMI: <18.5 = underweight; 18.5–24.9 = normal; 25.0–29.9 = overweight; 30.0–39.9 = obese.

Citation: The Salvadore DOI: 10.1211/PJ.2017.20203984

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