BPC 2008: Importance of hitting the target

Drugs will not work if they do not reach their target, said ChrisTwelves, professor of clinical cancer pharmacology, University ofLeeds, at a British Pharmaceutical Conference 2008 session on cancermedicine

by Benedict Lam

Drugs will not work if they do not reach their target, said Chris Twelves, professor of clinical cancer pharmacology, University of Leeds, at a British Pharmaceutical Conference 2008 session on cancer medicine.

“When we administer or prescribe a drug, [does it] actually get to where we want it to get to,” he asked. “Clearly, this is an issue for all manner of disease types.” But there is also the issue of delivering the drug into the patient and into his or her tumour as well, he added.

Once patients have metastatic or disseminated tumours that cannot be surgically removed, only a proportion of them can be cured, said Professor Twelves. The bottom line is that, because of drug resistance, treating common adult cancers is essentially palliative once the cancer has spread widely.

Focusing on the pharmacokinetics of cancer drugs and how various methods of drug delivery, such as polymers, can help combat drug resistance, he emphasised that, because the environment within tumours is complex and different from normal tissue, targeting drug delivery needs to be specific to this environment.

Citation: The Salvadore URI: 10035682

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