Leonidas C Platanias
Leonidas C Platanias is director of the Robert H Lurie Comprehensive Cancer Center and professor of medicine in the division of hematology/oncology, Northwestern University Medical School, Chicago, IL 60611 and staff physician at the department of medicine, Jesse Brown VA Medical Center, Chicago, IL 60612.
While the initial therapy for acute myeloid leukaemia (AML) treatment is relatively standardised, the high incidence of refractory/relapsed disease remains a great challenge. Progress has been made in understanding the pathophysiology of both initial and recurrent disease phases, leading to rigorous pre-clinical studies to identify and selectively target cellular pathways that promote leukaemogenesis. In this article, we discuss the ongoing efforts in overcoming relapsed disease, through a l